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Increased frequency of late pre‐β lipoproteins (LP β) in isolated serum very low density lipoproteins in uraemia
Author(s) -
NORBECK HANS ERIK,
CARLSON LARS A.
Publication year - 1980
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1980.tb02079.x
Subject(s) - very low density lipoprotein , medicine , endocrinology , triglyceride , chemistry , catabolism , cholesterol , beta (programming language) , lipoprotein , dialysis , ultracentrifuge , biochemistry , metabolism , computer science , programming language
. Hypertriglyceridaemia, which is caused by raised levels of the triglyceride rich serum very low density lipoproteins (VLDL), is common in uraemia. Here we report qualitative studies on VLDL in this condition. VLDL were isolated from serum of 137 uraemic patients by ultracentrifugation, subjected to agarose electrophoresis and stained for lipids. An increased frequency of presence of electrophoretically slow migrating, discrete VLDL band, the so‐called late pre‐β lipoproteins, LPβ, was found, 76% in uraemia versus 30% in controls. Patients on haemodialysis had a higher frequency of LPβ than those not on dialysis, 94% versus 69%. Furthermore the cholesterol/trigly‐ceride ratio of VLDL was raised by about 30% in uraemia. Since the cholesterol enriched LPβ is believed to represent an end stage of the catabolism of VLDL these data suggest that there is a delayed clearance of VLDL remnants in uraemia. In haemodialysis patients heparin might have contributed to the higher frequency of LPβ.