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Lipoprotein lipase in adipose tissue and plasma triglceride clearance in patients with primar hpertriglceridaemia
Author(s) -
TALOR K. G.,
HOLDSWORTH G.,
GALTON D. J.
Publication year - 1980
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1980.tb02072.x
Subject(s) - adipose tissue , lipoprotein lipase , very low density lipoprotein , medicine , endocrinology , lipoprotein , chemistry , lipase , enzyme , cholesterol , biochemistry
.1 The activit of lipoprotein lipase (E.C.3.1.1.3) extracted and released from adipose tissue has been measured in obese subjects with mild or severe hpertriglceridaemia. The Intralipid® tolerance test has been studied as a measure of in vivo clearance of exogenous triglceride from plasma. 2 Plasma triglceride clearance was reduced in patients with severe hpertriglceridaemia (> 4 mmol/1) and this was associated with reduced activities of extracted lipoprotein lipase in adipose tissue compared to patients with mild hpertriglceridaemia (2–4 mmol/1). 3 A course of insulin therap (20 u/da) for 1 week increased the extracted, but not the released component of the enzme from adipose tissue of hpertri‐glceridaemic patients. 4 Serum (25% v/v) potentiated the release of lipoprotein lipase from adipose tissue of normo‐ but not hpertriglceridaemic patients. 5 The effect of serum on enzme release was abolished if lipoprotein‐deficient serum was used. Addition of ver low densit lipoprotein (VLDL) or high densit liproprotein (HDL) restored the abilit of de‐lipidated serum to augment release of enzme from adipose tissue, but this was not observed with low densit lipoprotein (LDL). 6 It is suggested that a defect in the release of lipoprotein lipase activit in adipose tissue ma contribute to the development of hpertriglceridaemia in this group of patients.