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Effect of indomethacin upon the renin‐angiotensin sstem in patients with Bartter's sndrome
Author(s) -
VIERHAPPER H.,
WALDHAUSL W.,
Klinik I. Medizinische
Publication year - 1980
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1980.tb02070.x
Subject(s) - renin–angiotensin system , medicine , endocrinology , bartter's syndrome , angiotensin ii , plasma renin activity , blood pressure , endogeny , chemistry , aldosterone , bartter syndrome , hypokalemia
This stud reports on the influence of indomethacin upon the renin‐angiotensin sstem in three patients with Bartter's sndrome. An analogue of angiotensin II with weak agonistic properties (suc‐cinam 1 1 ‐val 5 ‐phenlglcine‐acetate 8 ‐angiotensin II) induced a fall of blood pressure and a rise of plasma renin concentration but no change in plasma aldosterone. Pretreatment with indomethacin (75 mg/da) reversed the hpotensive effect of the analogue of angiotensin II and abolished the increase of plasma renin concentration. It is concluded that elevated levels of endogenous angiotensin II are of major importance for the maintenance of blood pressure in patients with Bartter's sndrome. The inhibition of the snthesis of prostaglandins reversed some, though not all, of the metabolic abnormalities in this sndrome.