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Hormonal and metabolic characteristics of geneticall obese Zucker and dietar obese Sprague‐Dawle rats
Author(s) -
NOSADINI ROMANO,
URSINI FULVIO,
TESSARI PAOLO,
GAROTTI MARIA CHIARA,
BIASI FLORA DE,
TIENGO ANTONIO
Publication year - 1980
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1980.tb02069.x
Subject(s) - endocrinology , medicine , ketone bodies , glucagon , carnitine , insulin , chemistry , endocrine system , hormone , perfusion , population , obesity , metabolism , biology , environmental health
. The endocrine‐metabolic plasma pattern and the capacit of isolated perfused livers to produce triglcerides and ketone bodies have been studied in geneticall and diet‐acquired obese rats (Zucker and Sprague‐Dawle obese rats), and in control groups of the same strains. An increased plasma insulin/glucagon molar ratio with hperinsulinaemia and hpoglucagonaemia was associated with hpertriglceridaemia, normal ketonaemia, elevated free fatt acids and normal or slight hperglcaemia in obese rats. During oleate perfusion, the livers of Zucker and Sprague‐Dawle obese rats showed an increase in triglceride output and liver triglceride content. The ketone bod output as well as the mitochondrial carnitine palmitol transferase activit were normal or slightl decreased. In our rat population, a positive correlation between the insulin/glucagon molar ratio and triglceride output has been found.