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Acute ethanol ingestion and haem biosnthesis in health subjects
Author(s) -
McCOLL KENNETH E. L.,
THOMPSON GEORGE G.,
MOORE MICHAEL R.,
GOLDBERG ABRAHAM
Publication year - 1980
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1980.tb02068.x
Subject(s) - porphobilinogen deaminase , ferrochelatase , uroporphyrinogen iii decarboxylase , dehydratase , enzyme , biochemistry , chemistry , endocrinology , ingestion , medicine , porphyria , porphobilinogen synthase , heme , biology
. The effects of acute ethanol ingestion on the activities of the enzmes of haem biosnthesis in peripheral blood cells have been monitored in eight health subjects. The mitochondrial enzmes delta‐aminolaevulinic acid (ALA) snthase, coproporph‐rinogen oxidase and ferrochelatase were measured in leucoctes and the ctosolic enzmes ALA dehdratase, porphobilinogen (PBG) deaminase and uroporphrinogen decarboxlase in erthroctes. Ingestion of 1–316 mol ethanol resulted in increased activit of the rate‐controlling enzmes ALA snthase and PBG deaminase and decreased activit of the other four enzmes. There was also increased urinar excretion of coproporphrin. These observations ma be relevant to the biochemical mechanisms involved in the ethanol‐related conditions, sideroblastic anaemia, cutaneous hepatic porphria and hepatic siderosis.