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Parathyroid hormone fragments in secretory granules of human parathyroid adenomata
Author(s) -
MOHR HARALD,
HESCH ROLFD.,
McINTOSH CHRISTOPHER H. S.,
JOPPNER HARALD
Publication year - 1980
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1980.tb00039.x
Subject(s) - parathyroid hormone , immunoradiometric assay , chemistry , radioimmunoassay , size exclusion chromatography , parathyroid adenoma , granule (geology) , adenoma , medicine , endocrinology , biochemistry , biology , calcium , enzyme , paleontology , organic chemistry
. The composition of human parathyroid hormone immunoreactivity in the secretory granule fraction of parathyroid hormone adenomata was investigated. Granular extracts were separated by gel filtration and the eluates assayed by radioimmunoassay and sequence specific immunoradiometric assays detecting aminoterminal and carboxyterminal activity. About half of the extracted adenomata contained fragments besides intact hormone. The fragment composition varied from adenoma to adenoma.