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Increased plasma HDL‐cholesterol and apo A‐1 in sedentary middle‐aged men after physical conditioning
Author(s) -
KIENS BENTE,
JORGENSEN IDA,
LEWIS STEVEN,
JENSEN GORM,
LITHELL HANS,
VESSBY BENGT,
HOE STEEN,
SCHNOHR PETER
Publication year - 1980
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1980.tb00021.x
Subject(s) - medicine , cholesterol , endocrinology , apolipoprotein b , high density lipoprotein , physical exercise , vo2 max , blood lipids , chemistry , heart rate , blood pressure
. Previous studies have demonstrated an inverse relationship between plasma high density lipoproteins (HDL) cholesterol and coronary heart disease risk. In the present study we investigated prospectively the effect of a moderate physical conditioning programme on plasma lipids and lipoproteins, especially HDL‐cholesterol and apolipoprotein A‐I (apo A‐I), the major apoprotein of HDL. Healthy, sedentary, middle‐aged men were randomly selected and assigned either to a training group ( n = 24, age 40±3–4, mean ± SD) or to a control group ( n = 13, age 39±50). Training consisted of various indoor and outdoor sports activities 45 min/day, 3 times/week for 12 weeks at an intensity of approximately 80% of measured maximal oxygen uptake (VO 2 max). The trained subjects were studied at 4, 8 and 12 weeks. The training increased VO 2 max by 12% ( P < 0–01). Increases were observed in both apo A‐I (10%, P < 0 02) and HDL‐cholesterol (8%, P < 002) after training, with significant increases already after 4 and 8 weeks, respectively. Furthermore, decreases in total plasma cholesterol (5%, P < 0004) and plasma triglycerides (26%, P < 0 003) were found without changes in body weight, body composition, cigarette smoking, alcohol consumption or the percentage composition of dietary intake. Fasting serum‐insulin concentrations decreased significantly during training. No changes were noted in the control group. The present study demonstrates prospectively that moderate physical training can increase HDL.