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The effect of ethynyl oestradiol on biliary lipid composition in young men
Author(s) -
ANDERSON A.,
JAMES O. F. W.,
MACDONALD H. S.,
SNOWBALL S.,
TAYLOR W.
Publication year - 1980
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1980.tb00013.x
Subject(s) - medicine , endocrinology , molar , cholesterol , chenodeoxycholic acid , deoxycholic acid , phospholipid , composition (language) , chemistry , bile acid , biochemistry , dentistry , membrane , linguistics , philosophy
. A daily oral dose of 30 μg of ethynyl oestradiol was taken for 7 days by thirteen healthy young men. Bile was obtained by duodenal aspiration before and after treatment. The cholesterol saturation index of the bile was significantly greater after treatment due to an increase in the molar percentage of cholesterol and phospholipid and a decrease in the molar percentage of total bile acids. The oestrogen had no effect on cholic, deoxycholic and chenodeoxycholic acids expressed as a percentage of the total bile acids, and no change occurred in serum cholesterol. However, there was a significant decrease in serum testosterone concentration at the end of the treatment.