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Haemostatic effects of lysine vasopressin and triglycyl lysine vasopressin infusion in patients with cirrhosis
Author(s) -
PROWSEy C. V.,
DOUGLAS J. G.,
FORREST J. A. H.,
FORSLING M. L.
Publication year - 1980
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1980.tb00009.x
Subject(s) - vasopressin , lysine , cirrhosis , medicine , endocrinology , chemistry , biochemistry , amino acid
. Eight patients with cirrhosis were infused with lysine vasopressin (10 ng LVP) and triglycyl lysine vasopressin (750 μg and 2000 fig Glypressin, GVP) on separate occasions. LVP infusion resulted in an increase in factor VIII, factor VHI‐related antigen and plasminogen activator (PA). The factor VIII antigen: activity ratio decreased following infusion, but factor VIII electrophoretic mobility and in vitro decay rate were unchanged. GVP infusion produced no change in factor VIII or PA. Assay of vasopressin‐like antigen and antidiuretic activity showed that GVP is cleaved to LVP in vivo. The low levels of LVP formed by this reaction might explain the prolonged vasometer effects of GVP, as well as its inability to cause release of factor VIII or PA.