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Metabolism of endogenous plasma triglyceride in familial hypercholesterolaemia: studies of affected and unaffected siblings of two kindreds
Author(s) -
ANGELIN BO
Publication year - 1980
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1980.tb00005.x
Subject(s) - triglyceride , medicine , endocrinology , endogeny , metabolism , cholesterol , chemistry , biology
Abstract. Plasma endogenous triglyceride kinetics were investigated using [ 3 H]glycerol in five unaffected and eight affected (heterozygous) siblings of two kindreds with familial hypercholesterolaemia. No consistent differences between affected and unaffected siblings regarding plasma triglyceride levels or apparent triglyceride production rates as determined over 10 h were seen, and the values observed were generally within the ranges seen in twelve normolipidaemic controls. It is concluded that abnormal plasma triglyceride metabolism is not a feature of heterozygous familial hypercholesterolaemia.