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Beneficial effects of colchicine in experimental nephrotoxic serum nephritis in the rat
Author(s) -
PENCHAS S.,
CHARUZI I.,
BOSS J. H.
Publication year - 1979
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1979.tb01684.x
Subject(s) - colchicine , nephrotoxicity , nephritis , proteinuria , glomerulonephritis , medicine , kidney , endocrinology
. Glomerulonephritis was induced in rats by multiple injections of rabbit anti‐rat kidney serum. Colchicine was administered daily for 4 months to nephrotoxic serum treated rats and untreated control animals. Nephritic rats receiving colchicine had significantly less proteinuria and less glomerular damage than unprotected nephritic animals. A possible role for colchicine in the early treatment of human glomerulonephritis is suggested.