Premium
Chronic administration of chenodeoxycholic acid increases cholesterol saturation in bile in the dog
Author(s) -
POUPON R. E.,
POUPON R. Y.,
DUVAL M.,
QUERNEC L. LE,
ERLINGER S.
Publication year - 1979
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1979.tb01674.x
Subject(s) - chenodeoxycholic acid , cholesterol , medicine , bile acid , endocrinology , saturation (graph theory) , chemistry , gastroenterology , mathematics , combinatorics
. Six dogs were given chenodeoxycholic acid, 200 mg/day for 15 days; gallbladder and hepatic bile samples were taken and biliary bile acids, phospholipids and cholesterol were compared to those of fourteen control dogs. It was found that: (1) the cholesterol saturation index of gallbladder bile was higher in treated dogs (0.12 ± 0.06; m ± SD) than in controls (0.07 ± 0.01; P < 0.05); the proportion of chenodeoxycholic acid in gallbladder bile was higher in treated dogs (27.8 ± 12.5%) than in controls (4.5 ± 1.9%; P < 0.01); (2) in hepatic bile, the saturation index and proportion of chenodeoxycholic acid were significantly higher in treated dogs (respectively 0.13 ± 0.03 and 21.6 ± 8.8%) than in control dogs (respectively 0.07 ± 0.01; P < 0.01 and 4.6 ± 2.2%; P < 0.01). In the dog, chronic administration of chenodeoxycholic acid increases cholesterol saturation in bile. It is concluded that the difference of effect of chenodeoxycholic acid in man and in the dog is not related to the duration of administration, but to a species difference.