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Renin‐activation by kallikrein: evidence for alkaline‐activation of plasma renin
Author(s) -
HUMMERICH W.,
FELTKAMP H.,
KONRADS A.,
AHLMANN P.,
BORNHOFEN H.
Publication year - 1979
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1979.tb00911.x
Subject(s) - kallikrein , endogeny , chemistry , renin–angiotensin system , aprotinin , plasma renin activity , medicine , endocrinology , in vivo , biochemistry , enzyme , biology , blood pressure , microbiology and biotechnology
. Porcine pancreatic kallikrein leads to a significant activation of human plasma renin when incubated at pH 8·2. ‘Endogenous’ activation of plasma renin can be seen by incubation of plasmas at the same pH. Both ‘endogenous’ alkaline‐ and kallikrein‐activation of plasma renin can be inhibited by aprotinin. Both, kallikrein‐ and ‘endogenous’ alkaline activation of plasma renin are significantly correlated to cryo‐ and acid‐activation. We suggest that kallikrein‐ and ‘endogenous’ alkaline‐activation come close to the in vivo activation process.