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Abnormal cation composition and transport in erythrocytes from hypertensive patients
Author(s) -
ADEROUNMU A. FADEKE,
SALAKO L. A.
Publication year - 1979
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1979.tb00898.x
Subject(s) - potassium , efflux , sodium , red cell , medicine , essential hypertension , red blood cell , isotonic , endocrinology , chemistry , ouabain , sucrose , biochemistry , blood pressure , organic chemistry
. Red cell sodium and potassium were determined in 100 untreated subjects with uncomplicated essential hypertension and compared with the values from 908 healthy normotensive control subjects. Red cell sodium concentration (expressed as mmol/l of erythrocytes) was significantly higher in hypertensive than in normotensive subjects. Red cell potassium concentration (in mmol/l of erythrocytes) was not significantly different in the two groups. Passive efflux of red cell potassium into buffered isotonic sucrose solution determined in eight hypertensive and nine normotensive subjects showed a lower potassium efflux rate in the hypertensive subjects. Comparison of active sodium efflux in sixteen hypertensive and fourteen normotensive subjects showed that ouabain‐sensitive active sodium efflux was higher in red cells of normotensive than in those of hypertensive subjects.