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Capillary permeability in healthy males with different insulin response to glucose
Author(s) -
BERGLUND BO,
EFENDIĆ SUAD,
STRANDELL TORE,
LUFT ROLF
Publication year - 1979
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1979.tb00897.x
Subject(s) - insulin , medicine , endocrinology , peripheral , skeletal muscle , vascular permeability , permeability (electromagnetism) , insulin sensitivity , age groups , insulin resistance , chemistry , biochemistry , demography , membrane , sociology
. The capillary permeability in human skeletal muscle, expressed as capillary diffusion capacity (CDC) for 51 Cr‐EDTA, was determined during exercise with a local clearance method in two groups of healthy male subjects: a younger group with a mean age of 30 years and an older one with a mean age of 58 years. The main finding was that, in both age groups, CDC was significantly negatively correlated to the early phase of insulin response to an intravenous glucose load. No correlation was found between CDC and peripheral insulin sensitivity. CDC was significantly higher in the older age group ( P < 0·01) independent of insulin response, blood flow and body weight. These data indicate that subjects with low insulin response to glucose have a higher capillary permeability than high responders, and that muscle capillary permeability increases with age.