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Meal induced increase in serum triglycerides has no effect on lymphocyte response to mitogens
Author(s) -
SOPPI E.,
VIIKARI J.,
ESKOLA J.,
RUUSKANEN O.
Publication year - 1979
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1979.tb00885.x
Subject(s) - phytohaemagglutinin , concanavalin a , medicine , lymphocyte , endocrinology , meal , stimulation , tuberculin , cholesterol , chemistry , immunology , biology , biochemistry , in vitro , tuberculosis , pathology
. The effect of a standardized heavy meal on the lymphocyte transformations induced by phytohaemagglutinin (PHA), concanavalin A (Con A) and PPD tuberculin was studied. The meal significantly increased the serum triglycerides ( P < 0.01), while it had no effect on cholesterol or high density lipoproteincholesterol levels. The increase in serum triglycerides did not affect lymphocyte transformation induced by phytohaemagglutinin or concanavalin A in whole blood microcultures. A slight decrease was observed when lymphocytes were stimulated with one out of three concentrations of PPD tuberculin ( P < 0.05). However, there was no correlation with the increase of triglycerides and decrease in lymphocyte transformation. Our observation shows that physiological changes in serum triglycerides do not affect the capacity of lymphocytes to respond to mitogenic stimulation, and the whole blood micromethod for lymphocyte stimulation to screen the capacity of cell‐mediated immunity does not depend on the meal schedule of the patients.