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Anticlotting properties of fragments D from human fibrinogen and fibrin
Author(s) -
HAVERKATE F.,
TIMAN G.,
NIEUWENHUIZEN W.
Publication year - 1979
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1979.tb00881.x
Subject(s) - plasmin , fibrin , fibrinogen , chemistry , in vitro , biochemistry , biophysics , immunology , biology , enzyme
. It appeared from our previous studies that Ca 2+ concentrations comparable to those occurring in blood protect the C‐terminal part of the γ‐chain remnants of fibrin(ogen) fragments D against further plasmin attack. This study shows that purified fibrin(ogen) fragments D formed in the presence of Ca 2+ ions have anticlotting activity in vitro , whereas shortening of the γ‐chain remnants leads to loss of such activity.