Premium
Humoral hypercalcaemia in a patient with renal‐cell carcinoma
Author(s) -
POWELL DAVID,
MCPARTLIN JOSEPH,
SKRABANEK PETR
Publication year - 1978
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1978.tb00876.x
Subject(s) - hypercalcaemia , cyclase , adenylate kinase , medicine , endocrinology , renal cell carcinoma , peripheral blood , stimulation , parathyroid hormone , calcium , receptor
. In a patient with hypercalcaemia secondary to a renal‐cell carcinoma, a concentration gradient of bio‐activity was detected between the tumour effluent vein and the peripheral venous blood that was capable of stimulating adenylate cyclase in bone cells. Immuno‐reactive PTH was undetectable in the tumour effluent and in the peripheral blood. It is concluded that a non‐parathyroid humoral factor whose action involved cyclic AMP stimulation was responsible for the hypercalcaemia.