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Effect of continuously increasing concentrations of plasma ketone bodies on the uptake and oxidation of glucose by muscle in man
Author(s) -
WICKLMAYR M.,
DIETZE III G.
Publication year - 1978
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1978.tb00874.x
Subject(s) - ketone bodies , medicine , endocrinology , metabolism , chemistry , glucose uptake , carbohydrate metabolism , ketone , fatty acid , biochemistry , biology , insulin , organic chemistry
. Muscle metabolism in man was studied by measuring the arterial and deepvenous concentrations of glucose, lactate, pyruvate, free fatty acids, β‐hydroxy‐butyrate and acetoacetate, and forearm blood flow. After the subjects had fasted overnight, their arterial free fatty acid and ketone levels rose continuously during a period of 90 min, leading to increased ketone body uptake by muscle. Hence, for each subject, a relation was obtained between arterial concentrations and arterial‐deepvenous differences of P‐hydroxybutyrate and acetoacetate. As the ketone body utilization increased, the release of lactate rose as well. In spite of these alterations the uptake of glucose remained unchanged. These findings underline the current notion that accelerated ketone uptake reduces pyruvate oxidation but not glucose uptake by muscle.