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Increased excretion of two sialic acid‐containing trisaccharides in the urine of patients with rheumatoid arthritis
Author(s) -
MAURY PETER
Publication year - 1978
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1978.tb00872.x
Subject(s) - rheumatoid arthritis , excretion , chemistry , medicine , sialic acid , lactose , endocrinology , urinary system , urine , biochemistry
. The urinary excretion of sialic acid‐containing trisaccharides in patients with active rheumatoid arthritis was studied. Sialyl‐lactose and sialyl‐N‐acetyl‐lactosamine were identified and their excretion patterns studied by thin layer and gas chromatography. The urinary output of sialyl‐lactose was greater in patients with active rheumatoid arthritis (48.2 ± 6.1 nig/24 h, SEM, n = 6) than in healthy subjects (19.8 ± 3.7 mg/24 h, SEM, n = 5; P< 0.01). The excretion of sialyl‐N‐acetyllactosaniine was also higher in the rheumatoid group (18.5 ± 2.1 mg/24 h, SEM, n = 6) than in the controls (11.1 ± 1.2 mg/24 h, SEM, n = 5; P< 0.05). The qualitative excretion patterns of the sialyl‐oligo‐saccharide fraction were similar for the two groups as judged from the thin layer chromatograms. Correlating the results with the clinical state of the patients with rheumatoid arthritis suggests that the urinary level of the sialyl‐oligosaccharides reflects the activity of the disease. A proposed mechanism for the increased excretion of sialic acidcontaining trisaccharides in rheumatoid arthritis is presented.