Premium
Relationship of the activity of the bone isoenzyme of serum alkaline phosphataseto urinary hydroxyproline excretion in metabolic and neoplastic bone diseases
Author(s) -
ŠTĚPáN J.,
PACOVSKÝ V.,
HORN V.,
SILINKOVÁMÁLKOVÁ E.,
VOKROUHLICKÁ O.,
KONOPÁSEK B.,
FORMÁNKOVÁ J.,
HRBA J.,
MAREK J.
Publication year - 1978
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1978.tb00867.x
Subject(s) - osteomalacia , hydroxyproline , medicine , endocrinology , bone remodeling , osteoporosis , urinary system , excretion , alkaline phosphatase , metabolic bone disease , bone disease , acromegaly , bone resorption , chemistry , biochemistry , enzyme , hormone , growth hormone
. A significant correlation between the activity of the bone isoenzyme or serum alkaline phosphatase and the urinary hydroxyproline excretion in osteomalacia, osteoporosis, primary hyperparathyroidism with osteo‐dystrophy, Paget's disease, secondary bone tumours, and in a control group was found ( P< 0.001). This close correlation was not observed between these variables in patients with active acromegaly. Diagnosis determined from these indices of formation and turnover of bone matrix agreed with that established by histological and histochemical examination of bone, by X‐ray investigation of the skeleton, and by the radionuclear 85 Sr test. The relationship between the activity of bone isoenzyme and urinary hydroxyproline excretion differed in metabolic bone diseases with a high bone turnover, in patients with osteoporosis and in patients with early osteoclastic bone metastases.