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Plasma renin substrate sensitivity to oestrogens and oestrogen metabolism in cirrhosis
Author(s) -
DEGOS F.,
BENHAMOU J. P.,
MENARD J.,
SALMON J.,
RAYNAUD J. P.
Publication year - 1978
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1978.tb00859.x
Subject(s) - medicine , endocrinology , cirrhosis , basal (medicine) , plasma renin activity , chemistry , metabolism , excretion , alcoholic liver disease , renin–angiotensin system , insulin , blood pressure
. Oestrogen stimulation of plasma renin substrate (PRS) was studied in men with alcoholic cirrhosis. PRS values, before and I,2,4 and 6 days after a single oral administration of 100 pg of an oestrogen derivative, 11 β ‐methoxy‐17–ethynyl‐1,3,5(10)‐estratriene‐3,17 β ‐diol (Moxestrol), were measured by radioimmunoassay of generated angiotensin I in five men with normal liver function and five men with alcoholic cirrhosis. Basal PRS was 0.93 ± 0.22 nmol/ml (mean ± 1 SD) in the normal men and significantly lower (P<0.01) in the men with cirrhosis (0.33±0.14 nmol/ml). Two days after administration of Moxestrol, PRS rose significantly but transiently (P<0.05) to 1.41 ±0.42 nmol/ml in the normal men and to 0.47 ± 0.15 in the cirrhotic men, the relative increase (˜50%) being similar in both groups. A study of the plasma kinetics and urinary excretion of Moxestrol was also performed to evaluate its metabolic clearance rate and absorption. Since the intestinal absorption of [ 14 C] Moxestrol was not depressed in cirrhotic men, the low PRS values recorded are probably the consequence of hepatocyte dysfunction.