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Polymorphic acetylation and aminopyrine demethylation in Gilbert's syndrome
Author(s) -
PLATZER R.,
KÜPFER A.,
BIRCHER J.,
PREISIG R.
Publication year - 1978
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1978.tb00856.x
Subject(s) - medicine , gilbert's syndrome , gastroenterology , breath test , acetylation , population , endocrinology , chemistry , biochemistry , bilirubin , environmental health , gene , helicobacter pylori
. Polymorphic acetylation was investigated in twenty‐seven patients with Gilbert's syndrome using the sulphadimidine test. Whereas the finding of 51% slow acetylators in seventy‐eight control persons agreed well with the expected frequency in a continental European population, the prevalence of slow acetylators in Gilbert's syndrome was increased to 78% ( P<0.03 , Woolfs G‐test). After oral administration of 14 C‐aminopyrine there was no significant difference between seventeen patients with Gilbert's syndrome and twenty‐seven normal controls in total plasma clearance of aminopyrine (280 ± SD 100 and 270 ± 60 ml/min) and in the disappearance curve of 14 CO 2 in breath (0.23 ± 0.04 and 0.22 ± 0.03 h ‐1 respectively). Thus, whereas aminopyrine metabolism appears unaffected in the examined patients, the data documents a new association between slow acetylator status and Gilbert's syndrome.