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Initial cholesterol esterif ication rate in hyperlipoproteinaemia: effects of triglyceride‐rich Iipoproteins
Author(s) -
PATSCH W.,
LISCH H.J.,
SAILER S.,
BRAUNSTEINER H.
Publication year - 1978
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1978.tb00854.x
Subject(s) - triglyceride , cholesterol , chemistry , medicine
. The initial cholesterol esterification rate (LCAT activity) was determined in ninety‐four hyper‐lipidaemic subjects. LCAT activity was elevated in hypertriglyceridaemia, whereas patients with hyper‐cholesterolaemia had normal activities. In hypertri‐glyceridaemic subjects LCAT activity correlated with the concentrations of d 1.006 lipoproteins, plasma triglycerides, cholesterol and cholesterol esters and phospholipid levels. Addition of d < 1.006 lipoproteinto normal plasma resulted in a dose dependent stimulation of enzyme activity with a sigmoidal response curve. When the d < 1.006 lipoproteins were removed from hypertriglyceridaemic plasma by ultracentrifugation, the enzyme activity in the residual d > 1.006 fraction dropped, but still was higher than in normal plasma and correlated with the amount of d 1.006 lipoproteins originally present. Thus, high LCAT activity in hypertriglyceridaemia cannot be explained solely by the presence of an increased d < 1.006 lipoprotein concentration. An increase of enzyme concentration or changes in concentration or composition of other lipoproteins (high density lipoproteins) may contribute to the high LCAT activity in hypertriglyceridaemia.