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Interactions of calcium, magnesium and atropine on exocrine pancreatic secretion in man
Author(s) -
HOTZ J.,
GOEBELL H.,
ZIEGLER R.
Publication year - 1978
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1978.tb00846.x
Subject(s) - secretin , endocrinology , atropine , medicine , calcium , secretion , chemistry , extracellular , bicarbonate , magnesium , pancreatic juice , enzyme , pancreas , biochemistry , organic chemistry
. The effects of the intravenous administration of atropine or magnesium on pancreatic secretion which has been stimulated by secretin and induced hypercal‐caemia have been studied in man. In the presence of secretin (0.5 CU/kg.h) the infusion of Ca 2+ (0.3 mmol/kg.105 min) resulted in an increase in secretion of enzymes by 100–200%, and in that of Ca 2+ and Mg 2+ by 50–100% without affecting fluid and bicarbonate secretion. The additional injection of atropine (0.5 mg i.v. and 0.5 mg s.c.) were followed by a prompt fall in enzymes but not in Ca 2+ and Mg 2+ to the secretin‐stimulated values. The additional infusion of Mg 2+ (0.12 mmol/kg.45 min) to the Ca 2+ ‐infusion did not alter the secretion of enzymes, Ca 2+ or Mg 2+ compared with the calcium infusion alone. It is suggested that the hypercalcaemic stimulus depends on an intact innervation of the acinar cells. In these experiments the secretion of Ca 2+ and Mg 2+ seem to originate mainly from extracellular fluxes.