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Plasma phenylethanolamine in hepatic encephalopathy
Author(s) -
CANGIANO C.,
ROSSIFANELLI F.,
BOZZI A.,
CALCATERRA V.,
CASCINO A.,
CAPOCACCIA L.
Publication year - 1978
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1978.tb00833.x
Subject(s) - hepatic encephalopathy , medicine , endocrinology , encephalopathy , cirrhosis , pathogenesis , phenylethanolamine , neurotransmitter , dopamine , chemistry , gastroenterology , central nervous system , tyrosine hydroxylase
. It has been suggested that mines other than octopamine may be involved in the pathogenesis of hepatic encephalopathy. Plasma phenylethanolamine has been determined by a radioenzymatic method in twenty‐six biopsy‐proven cirrhotics with or without encephalopathy and in seven normal adults. Phenylethanolamine plasma levels correlated statistically with the presence of liver cirrhosis and severe coma. These results are consistent with the false neurotransmitter hypothesis of hepatic encephalopathy.