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Metabolism of apolipoproteins A‐I and A‐ll and its influence on the high density lipoprotein subfraction distribution in males and females
Author(s) -
SHEPHERD JAMES,
PACKARD CHRISTOPHER J.,
PATSCH JOSEF R.,
GOTTO ANTONIO M.,
TAUNTON O. DAVID
Publication year - 1978
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1978.tb00823.x
Subject(s) - medicine , endocrinology , metabolism , lipoprotein , catabolism , apolipoprotein b , high density lipoprotein , ultracentrifuge , distribution (mathematics) , chemistry , biology , cholesterol , biochemistry , mathematics , mathematical analysis
. Rate zonal ultracentrifugation of plasma samples from ten healthy age‐matched volunteers (five males, five females) indicated that the high density lipoprotein subfraction ratio (HDL 2 :HDL 3 ) in females was significantly higher than in males. The cause of this phenomenon was investigated by simultaneous examination of the metabolism of the major HDL apoproteins (apoA‐I and apoA‐II) in both groups. The results show that there is no significant sex‐related difference in the plasma pool size, fractional catabolic rate, or synthetic rate of either apoprotein. We conclude that the increased HDL 2 :HDL 3 ratio in females versus males does not derive from measurable differences in the metabolic handling of either apoprotein.