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Lowering of serum 3,3‘,5‐triiodothyronine thyroxine ratio in patients with myocardial infarction; relationship with extent of tissue injury
Author(s) -
SMITH S. J.,
BOS G.,
GERBRANDY J.,
DOCTER R.,
VISSER T. J.,
HENNEMANN G.
Publication year - 1978
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1978.tb00819.x
Subject(s) - myocardial infarction , triiodothyronine , medicine , endocrinology , infarction , radioimmunoassay , cardiology , thyroid
. Serial measurements of haematocrit (Ht), plasma thyroxine (T 4 ), triiodothyronine (T 3 ) and α‐hydroxybutyrate dehydroxygenase (α‐HBDH) were performed in patients following myocardial infarction (MI). Infarct size was estimated by mathematical analysis of the change in plasma α‐HBDH activity with time. After an initial small increase Ht decreased 12% until day 9 and remained constant thereafter. Serum T 4 did not change during the entire study. Serum T 3 decreased to 66% at day 9 and then returned to normal within 2 months. These figures are expressed relative to determinations in the first blood sample obtained within 12 h after MI. A significant correlation between the lowest serum T 3 /T 4 ratio and infarct size was observed. These observations suggest that in these patients the peripheral conversion of T 4 into T 3 is reduced. This was accompanied by an increased production of reverse T 3 as evidenced by observations in one patient.