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Bile acid pattern in human amniotic fluid
Author(s) -
DÉLÈZE G.,
PAUMGARTNER G.,
KARLAGANIS G.,
GIGER W.,
REINHARD M.,
SIDIROPOULOS D.
Publication year - 1978
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1978.tb00807.x
Subject(s) - amniotic fluid , bile acid , chemistry , biology , pregnancy , biochemistry , fetus , genetics
Individual bile acids were determined in twenty‐nine amniotic fluid specimens obtained from twenty‐six women between the 32nd and 41st week of gestation. Total bile acid concentration ranged from 0.4 to 4.8μmol/1 with a mean of 1.57μmol/l. Besides the two major bile acids of man, cholic acid and chenodeoxy‐cholic acid, 3β‐hydroxy‐5‐cholenoic acid was found in all, lithocholic acid in ten and deoxycholic acid in nine of the twenty‐nine amniotic fluid samples. 3β‐Hydroxy‐5‐cholenoic acid averaged 39.8% of total bile acids during 32–37 weeks of gestation and 20.2% at term (P<0.01). These findings point towards important differences between fetal and adult bile metabolism and may reflect maturation of hepatic bile acid biosynthesis near term.