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Hepatic collagen proline hydroxylase activity in primary biliary cirrhosis
Author(s) -
JAIN STEPHAN,
SCHEUER P. J.,
McGEE J. O'D.,
SHERLOCK SHEILA
Publication year - 1978
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1978.tb00802.x
Subject(s) - primary biliary cirrhosis , cirrhosis , medicine , enzyme , proline , endocrinology , gastroenterology , biliary cirrhosis , chemistry , enzyme assay , biochemistry , amino acid , disease , autoimmune disease
. The enzyme collagen proline hydroxylase has been measured in liver biopsies from fourteen patients with primary biliary cirrhosis. The activity was elevated in ten of the patients, but not to the degree previously found in patients with active cirrhosis. There was no correlation between the enzyme activity and the liver copper concentration, which was elevated in all except one of those measured. This suggests that excessive collagen synthesis in PBC is not directly related to the high liver copper concentrations.