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Serum immunoreactive prolyl hydroxylase in liver disease
Author(s) -
TUDERMAN LEENA,
RISTELI JUHA,
MIETTINEN TATU A.,
KIVIRIKKO KARI I.
Publication year - 1977
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1977.tb01648.x
Subject(s) - primary biliary cirrhosis , gastroenterology , cirrhosis , medicine , liver function tests , hepatitis , alcoholic liver disease , acute hepatitis , liver disease , liver function , pathology
. The concentration of serum immunoreactive prolyl hydroxylase (SIRPH) was measured in thirty patients with chronic active hepatitis, thirteen with primary biliary cirrhosis, four with alcoholic or idiopathic cirrhosis, and four with acute hepatitis; the values were compared with those in twenty‐three control subjects. Increases in SIRPH were found in all the groups with liver diseases, individual values being highest in primary biliary cirrhosis in which about two‐thirds of patients had values more than two standard deviations above the mean value in the control subjects. No correlation was found between SIRPH and other tests of liver function or some routine laboratory tests. SIRPH may reflect some hitherto unknown or unmeasured process in the diseased hepatic cells.