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Urinary kallikrein and changes in endogenous aldosterone in the rat
Author(s) -
MIMRAN ALBERT,
BAUDIN GÉRARD,
CASELLAS DANIEL,
SOULAS DOMINIQUE
Publication year - 1977
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1977.tb01642.x
Subject(s) - kallikrein , endocrinology , natriuresis , medicine , sodium , aldosterone , chemistry , low sodium diet , urinary system , excretion , low sodium , mineralocorticoid , diuresis , kidney , renin–angiotensin system , blood pressure , biochemistry , enzyme , organic chemistry
. Urinary kallikrein excretion was studied during changes in sodium intake. The effect of short‐term (5 days) and long‐term (4 weeks) sodium restriction was also investigated. In order to provide additional evidence for a primary role of endogenous aldosterone on the renal kallikrein system, the effect of dietary potassium restriction was studied in chronically sodium depleted rats.1 Chronic (4 weeks) sodium restriction was associated with high urinary kallikrein excretion (6.21 ± 0.31 i.u./24 h/100 g body weight). Urinary kallikrein was lower in high salt and normal salt rats (2.38 ± 0.18 and 2.71 ± 0.18 i.u./24 h/100 g bw). A negative correlation ( r = ‐0.88, P <0.001) between urinary kallikrein and the logarithm of natriuresis was obtained. 2 Positive correlations between urinary kallikrein and diuresis were obtained within each group of rats equilibrated with different sodium intakes. 3 When chronically sodium loaded rats were given a low sodium diet for a 5‐day period, urinary kallikrein increased from 1.99 ± 0.17 to 3.64 ± 0.3 i.u./24 h/100 g bw ( P <0.001). The mean value achieved after 5 days of sodium restriction was significantly lower ( P <0.001) than the value obtained in long‐term (4 weeks) sodium depleted rats. 4 When low sodium rats were fed a low sodium‐low potassium diet for 7 days, urinary kallikrein decreased by 34 ± 8% ( P <0.005) and urinary aldosterone fell from 112 ± 27 to 43 ± 11 ng/24 h ( P <0.01). Natriuresis remained constant throughout the study.These results suggest that endogenous aldosterone is one of the main determinant of renal kallikrein activity. Kallikrein may participate in the regulation of water excretion. In addition, the kallikrein‐kinin system may be involved in the renal adaptation to long‐term sodium restriction in the rat.