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Consequences of myocardial reperfusion following temporary coronary occlusion in pigs: effects on morphologic, biochemical and haemodynamic findings
Author(s) -
ALTHAUS U.,
GURTNER H. P.,
BAUR H.,
HAMBURGER S.,
ROOS B.
Publication year - 1977
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1977.tb01631.x
Subject(s) - coronary occlusion , hemodynamics , medicine , occlusion , cardiology , ligation , myocardial infarction , coronary circulation , blood flow
. The effects of myocardial reperfusion have been examined following a I h coronary occlusion and compared to a permanent coronary ligation in pigs. Haemodynamic investigations were carried out through‐out the surgical intervention and repeated after 7 days. Cellular injury was estimated by serial serum enzyme determinations (creatin phosphokinase, α‐hydroxybutyric dehydrogenase, aspartate aminotransferase, lactic dehydrogenase) during the first 5 postoperative days; infarct size was assessed morphometrically by a histo‐chemical staining procedure I week after the temporary or permanent coronary occlusion. A linear correlation was found between the logarithmically plotted peak serum activity of AST, HBDH, CPK and the morphometrically determined infarct size. Based upon enzyme and morphometrical studies no significant difference could be detected between the two experimental groups. In the animals subjected to transient coronary occlusion, however, the development of a ventricular aneurysm had been prevented by early and sustained reperfusion. Early re‐establishment of coronary circulation appears to accelerate the proliferation of a more resistant granulation tissue into the infarcted area. Cardiac performance was not improved by myocardial reperfusion.