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Plasma secretin concentration in man: effect of intraduodenal glucose, fat, amino acids, ethanol, HCI, or ingestion of a meal
Author(s) -
FAHRENKRUG J.,
MUCKADELL O. B. SCHAFFALITZKY DE
Publication year - 1977
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1977.tb01598.x
Subject(s) - postprandial , secretin , medicine , chemistry , endocrinology , ingestion , duodenum , meal , hydrochloric acid , tonicity , ethanol , biochemistry , insulin , pancreas , inorganic chemistry
. The effect of infusing isotonic saline, isotonic and hypertonic glucose, fat emulsion, amino acids, ethanol, and hydrochloric acid into the duodenum on the plasma concentration of immunoreactive secretin was studied in seven normal subjects. Only hydrochloric acid showed any effect. After acidification of the duodenum with hydrochloric acid a significant rise in plasma secretin concentration was observed from 1.3 ± 0.4 pmol X 1 ‐1 (mean ± SEM) to a peak value of 13.0 ± 1.2 pmol X 1 ‐1 after 5 min. The concentration returned to the basal level within 15 min. In eight other normal subjects the plasma secretin concentration was measured after the ingestion of a protein‐rich meal. No significant changes were observed during the 2 h postprandial period.