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Biochemical measurements in Paget's disease of bone
Author(s) -
WALTON R. J.,
PRESTON C. J.,
BARTLETT M.,
SMITH R.,
RUSSELL R. G. G.
Publication year - 1977
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1977.tb01567.x
Subject(s) - hydroxyproline , alkaline phosphatase , paget's disease of bone , medicine , chemistry , excretion , endocrinology , phosphate , calcium , biochemistry , disease , enzyme
. In a group of eighty‐three patients with untreated Paget's disease of bone, plasma alkaline phosphatase activity (AP), plasma non‐protein‐bound hydroxyproline concentration (PHP) and urinary excretion rate of total hydroxyproline (THP) were closely correlated with each other but not with fasting plasma concentrations of calcium or inorganic phosphate. Probit plots of AP and THP showed log‐normal distributions overlapping the normal ranges.