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Electron Microscopic Characterization of Lipoproteins from Patients with Familial Type III Hyperlipoproteinaemia
Author(s) -
Patsch J. R.,
Sailer S.,
Braunsteiner H.,
Forte T.
Publication year - 1976
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1976.tb00525.x
Subject(s) - ultracentrifuge , electron density , chemistry , plasma lipoprotein , low density lipoprotein , electron microscope , lipoprotein , characterization (materials science) , plasma , materials science , cholesterol , biochemistry , physics , nanotechnology , quantum mechanics , optics
The lipoproteins of very low density, low density and intermediate density were isolated by zonal ultracentrifugation from the plasma of subjects with familial type III hyperlipoproteinaemia and studied by electron microscopy. Each of these lipoproteins exhibited a spherical shape when free‐standing. The very low density, low density and intermediate density lipoproteins ranged in diameter from 31 ‐ 80, 17 ‐ 23, and 21 ‐ 35 nm, respectively. These results are consistent with, our previous findings that the intermediate density lipoprotein particles characteristic of plasma from type III subjects exhibit properties which are intermediate between those of very low density and low density lipoproteins.