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Renin‐Aldosterone Axis in Ethanol Intoxication and Hangover
Author(s) -
Linkola J.,
Fyhrquist F.,
Nieminen M. M.,
Weber T. H.,
Tontti K.
Publication year - 1976
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1976.tb00511.x
Subject(s) - aldosterone , plasma renin activity , ethanol , renin–angiotensin system , medicine , endocrinology , stimulation , dehydration , chemistry , blood pressure , biochemistry
The renin‐aldosterone system was studied in human volunteers during ethanol intoxication and hangover. Plasma renin activity increased more than 100%, when 1.5 ‐ 2.3 g ethanol per kg body weight was ingested over a three hour period. During hangover the increase even exceeded 200%. Plasma aldosterone concentration decreased during ethanol intoxication, but increased greatly during hangover. It is suggested that the stimulation of the renin‐aldosterone axis during ethanol intoxication and hangover is due to dehydration and increased activity of the sympathetic nervous system.