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The Effect of Spironolactone on Transport of Na + ., K + and H + . A Microperfusion Study in Rat Main Submaxillary Duct *
Author(s) -
Knauf H.,
Pander K.,
Franck S.
Publication year - 1976
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1976.tb00488.x
Subject(s) - chemistry , reabsorption , lumen (anatomy) , spironolactone , endocrinology , medicine , duct (anatomy) , excretory system , secretion , ion transporter , biophysics , sodium , ion , anatomy , biochemistry , biology , aldosterone , organic chemistry
The epithelium of the main excretory duct of the rat submaxillary gland was used as a target tissue for studies on the effect of a spironolactone on electrolyte transport. The spironolactone decreased net Na + reabsorption by 27 % and net K + secretion by 23 %. HCO3 was found to be about 2‐fold accumulated in the duct lumen, which was considered to result from decreased H + ion secretion. The results can be reconciled with an action of spironolactone on 1) the peritubular Na + ‐K + ‐exchange mechanism and 2) the functional coupling of Na + entry from lumen to cell with K + and H + transfer from cell to lumen.