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Defective Thyroglobulin Endocytosis and Hydrolysis in Thyroid Cold Nodules 1
Author(s) -
HoveVandenbroucke M.F.,
CouvreurEppe M.,
Visscher M.
Publication year - 1975
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1975.tb02289.x
Subject(s) - thyroglobulin , pinocytosis , thyroid , follicular phase , medicine , endocrinology , chemistry , endocytosis , thyroid nodules , hydrolysis , catabolism , metabolism , biology , biochemistry , receptor
The catabolic phase of thyroid secretion has been studied by incubating thyroid slices with 0.1 % 125 ***I thyroglobulin (Tg) in the following cases: ***11 follicular adenomas (FA), 8 hyerplastic nodules in multinodular glands (NM), 3 carcinomas (follicular or papillary, FC, PC) and normal (N) or micronodular tissue (M). Tg pinocytosis is severely impaired in all cold nodules (25 to 60 % reduction). In the follicular tumours (FA, FC), Tg hydrolysis is more affected than would be expected based only on reduced Tg endocytosis: the hydrolysis products remain in the phagolysosomes instead of being secreted. As far as the acid hydrolases are concerned these enzymatic activities are increased in nearly all nodules, in Particular in follicular adenomas and carcinomas.