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Transport ATPases of Cardiac Sarcolemma in 20, 25‐Diazacholesterol Induced Myopathy
Author(s) -
Fiehn W.,
Seiler D.,
Kuhn E.,
Bartels D.
Publication year - 1975
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1975.tb00461.x
Subject(s) - sarcolemma , medicine , myotonic dystrophy , myotonia , endocrinology , creatine kinase , stimulation , skeletal muscle , atpase , cardiac muscle , chemistry , muscular dystrophy , myopathy , enzyme , biochemistry
. 20, 25‐Diazacholesterol, known to induce myotonia in skeletal muscle, also affects cardiac muscle as can be concluded from the development of cardiomegaly. At the same time (Na + , K + ) ATPase of cardiac sarcolemmal membranes of the 20, 25‐diazacholesterol treated rats showed an increased activity as compared with control animals (91 % and 46 % stimulation respectively). The Ca ++ stimulated ATPase showed the same tendency (96 % and 64 % stimulation). In the plasma of the treated rats creatine phosphokinase activity was found to be elevated whereas the amount of protein‐bound iodine was decreased, a finding that is common in myotonic dystrophy.