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Effects of Insulin and of NSILA‐S on the Perfused Rat Heart: Glucose Uptake, Lactate Production and Efflux of 3–0‐Methyl Glucose
Author(s) -
Meuli C.,
Froesch E. R.
Publication year - 1975
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1975.tb00433.x
Subject(s) - insulin , medicine , perfusion , efflux , endocrinology , glucose uptake , chemistry , biochemistry
. 200 μU of insulin per ml perfusion medium stimulated glucose uptake and lactate production by the isolated perfused rat heart about 5 and 10 fold, respectively. Nonsuppressible insulin‐like activity (NSILA‐S) extracted from human serum had almost the same maximal effects. Mol per mol the two substances were equally effective and, correspondingly, the dose‐response curves were very similar. NSILA‐S accelerated the efflux of 3–0‐methyl glucose from the heart cells to the same extent as insulin. It can be concluded that NSILA‐S acts on heart muscle in a very similar way to that of insulin.