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Changes in Insulin Immunoreactivity across the Coronary Circulation in Man during Infusions of Glucose and a Fat Emulsion
Author(s) -
Carlson L. A.,
Kaijser L.,
Rossner S.,
Wahlqvist M. W.,
Wide L.
Publication year - 1975
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1975.tb00428.x
Subject(s) - insulin , medicine , coronary sinus , endocrinology , cardiology , fat emulsion , parenteral nutrition
. The extraction of immunoreactive insulin by the human heart has been examined using the technique of coronary sinus catheterisation. The subjects were 12 male volunteers. During the study infusions of a fat emulsion and glucose were given in an effort to create a “steady fed state”. The higher arterial insulin immunoreactivities which were observed during the infusions were associated with greater arterial coronary sinus differences in insulin immunoreactivity. The possibility of insulin degradation by the heart is discussed. During prolonged exercise the process of insulin removal by the heart appeared more active.