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Liver Inclusions in Erythropoietic Protoporphyria
Author(s) -
Wolff K.,
WolffSchreiner E.,
Gschnait F.
Publication year - 1975
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1975.tb00424.x
Subject(s) - erythropoietic protoporphyria , porphyria cutanea tarda , porphyria , paracrystalline , pathology , liver disease , electron microscope , disease , medicine , chemistry , protoporphyrin , biochemistry , porphyrin , physics , optics , crystallography
. Needle‐like inclusions have been found, by electron microscopy, in the livers of two unrelated patients with erythropoietic protoporphyria. Since they have not been noted in other hepatic conditions but do occur in the livers of protoporphyric mice it is suggested that they represent markers for proto‐porphyric liver disease. Paracrystalline inclusions that have been previously described in Wilson's disease and porphyria cutanea tarda were also present in the hepatocytes of one of these patients.