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Clearance of Antipyrine‐Dependence of Quantitative Liver Function
Author(s) -
Andreasen Per Buch,
Ranek Leo,
Statland Bernard E.,
Tygstrup Niels
Publication year - 1974
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1974.tb02325.x
Subject(s) - liver disease , medicine , albumin , drug , liver function , prothrombin time , endocrinology , liver function tests , serum albumin , drug metabolism , chemistry , liver enzyme , metabolism , pharmacology
. The purpose of the present study was to assess the influence of liver disease on the hepatic drug‐metabolizing enzyme systems. The clearance of antipyrine was found to be significantly decreased in 13 patients with liver disease compared with 9 control patients (18.5 and 58.6 ml/min. respectively). Among the patients with liver disease, those with a severely reduced capacity for work had significantly lower clearance of antipyrine than non incapacitated patients (12.5 and 25.4 ml/min. respectively). The clearance of antipyrine was significantly correlated with the galactose elimination capacity, the serum albumin and the prothrombin values. The results indicate that the drug‐metabolizing capacity of the liver changes in parallel with the other metabolic functions, and the use of the clearance of antipyrine as a quantitative test of liver function is suggested.