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Recovery of Function and Structure of Dog Ileum and Colon Following Two Hours' Acute Ischaemia *
Author(s) -
Robinson J. W. L.,
Haroud M.,
Winistorfer B.,
Mirkovitch V.
Publication year - 1974
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1974.tb00418.x
Subject(s) - ileum , ischemia , medicine , pathological , intestinal mucosa , efferent , infiltration (hvac) , pathology , gastroenterology , endocrinology , biology , afferent , physics , thermodynamics
. Loops of dog small intestine and colon have been subjected to two hours' acute ischaemia and their recovery has been studied by functional and histological examinations. – Immediately after the ischaemia, both organs show serious necrotic lesions of the mucosal surface, their active transport capacities are abolished, mucosal Na + ‐K + ‐ATPase activities are reduced, and a significant liberation of acid phosphatase into the efferent blood is observed. The lesions of the ileal loops are more severe than those of the colonic loops. – The ileal loops have a finite, albeit greatly reduced function 24 hours after the trauma. After 3 days, amino‐acid transport has normalised but sugar transport is still reduced. Histological examination confirms that epithelial cells cover the villi of most samples after 24 hours, and normalisation is almost complete after three days. All parameters are normal after one week. – In five cases out of eight, the colonic mu cosa is replaced by a compact polymorphonuclear infiltration bathing in a haemorrhagic exudate 24 hours after the ischaemic period; it is evidently quite functionless. In three loops the mucosa is preserved, but only one had functional activity. Three days after the trauma, functional activity is finite, but lower than that of the control loops; histological study reveals a disorganised mucosa, often with ulcers surrounded by relatively healthy tissue. At seven days, mean transport capacity is normal but there are still pathological signs at the microscopic level. – The results show that the ileum is more sensitive to ischaemic damage, but has a greater regenerative potential than the colon. There is a good relationship between the functional and structural state of the tissues.