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Renal and Cardiovascular Effect of Prostaglandin A 2 in Hypertensive Patients
Author(s) -
Hornych Antonin,
Safar Michel,
Papanicolaou Nicolas,
Meyer Philippe,
Milliezy Paul
Publication year - 1973
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1973.tb02205.x
Subject(s) - renal blood flow , diuresis , hemodynamics , medicine , kidney , endocrinology , blood pressure , cardiac output , renal circulation , prostaglandin , blood flow
. The haemodynamic and renal effects of synthetic prostaglandin A 2 (PGA 2 ) have been studied in 10 hypertensive subjects during a) a short lasting infusion of hypotensive doses of 3–9μg/kg min. of PGA 2 ; b) a continuous infusion starting with subdepressive doses and extended with hypotensive doses.—The rapid hypotensive effect observed with high doses was accompanied by an increase in cardiac output and renal blood flow without significant changes in the peripheral vascular bed. Hepatic blood flow was decreased. These observations show a preferential renal redistribution of cardiac output. During the administration of subdepressive doses of PGA., a marked renal effect was observed, consisting in an increase in free water clearance and diuresis with no significant modifications of general haemodynamics. The natriuretic effect was much less pronounced suggesting that PGA 2 is not a specific natriuretic hormone.—The haemodynamic and renal effects of endogenous PGs may play an important role in renal functions and in blood pressure regulation.