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The Effect of Clofibrate on the Elimination of Cholesterol as Bile Acids in Patients with Hyperlipoproteinaemia Type II and IV
Author(s) -
Einarsson Kurt,
Hellström Kjell,
Kallner Mora
Publication year - 1973
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1973.tb00361.x
Subject(s) - clofibrate , chenodeoxycholic acid , cholic acid , medicine , bile acid , chemistry , cholesterol , endocrinology
. The turnover of 14 C‐cholic acid and 3 H‐chenode‐oxycholic acid was studied in hyperlipaemic patients before and during treatment with clofibrate. ‐ Before therapy the total formation of bile acids recorded for 6 patients with hyperlipoproteinnemia type Il (387± 70 mg/day, mean ± S.E.) was considerably less than that encountered for 6 patients with hyperlipoproteinaemia type IV (1 379 ± 221 mg/day). This difference was mainly due to a high synthesis of cholic acid in the latter patients. ‐ The administration of clofibrate had no consistent effect on the half‐life, pool size and turnover of the bile acids in the patients with type II lipoprotein pattern. The combined synthesis of cholic acid and chenodeoxycholic acid decreased in all patients with hyperlipoproteinaemia type IV and amounted on average to 549± 97 mg/day. The effect on the formation of chenodeoxycholic acid was insignificant but the turnover of cholic acid decreased from 1076± 243 to 333 ± 85 mg/day.