Premium
The Effect of the β‐Receptor Blockade (Propranolol) on the Endocrine and Exocrine Pancreatic Function in Man after the Administration of Intestinal Hormones (Secretin and Cholecystokinin‐Pancreozymin)
Author(s) -
Raptis S.,
Dollinger H.,
Chrissiku M.,
Rothenbuchner G.,
Pfeiffer E. F.
Publication year - 1973
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1973.tb00345.x
Subject(s) - propranolol , endocrinology , medicine , secretin , cholecystokinin , endocrine system , hormone , insulin , cholecystokinin receptor , gastrointestinal hormone , secretion , chemistry , receptor , peptide hormone
. The effect of propranolol on the induction of endocrine and exocrine pancreatic function by secretin (SC) and cholecystokinin‐pancreozymin (CCK/PZ) was investigated in 35 metabolically normal subjects. Insulin secretion could be inhibited by propranolol after administration of glucose or SC. On the other hand it was not possible to inhibit the CCK/ P2 induced insulin secretion by propranolol. Exocrine pancreatic function was not influenced by the administration of propranolol. Our results suggest that the action of SC on the islet system, like that of glucose, is linked to the β‐adrenergic system.