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Simultaneous Quantitative Measurement of 131 I‐Iodine and 99 mTc‐Pertechnetate Uptake by Human Salivary Glands Using Scintiscanning with Validation by Direct Estimation in Biopsy Samples
Author(s) -
Lazarus J. H.,
Stephen K. W.,
Harden R. McG.,
Robertson J. W. K.,
Lister G.
Publication year - 1973
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1973.tb00344.x
Subject(s) - submandibular gland , pertechnetate , parotid gland , chemistry , nuclear medicine , saliva , technetium , salivary gland , iodide , iodine , biopsy , medicine , endocrinology , pathology , organic chemistry
.131 I‐iodide and 99 Tc‐pertechnetate concentration in human salivary glands has been measured simultaneously in vivo by quantitative scintiscanning in 7 thyrotoxic subjects. The mid scan times were 5, 12 and 20 min. and the gland to plasma ratio (G/P) of 131 I rose to 4.03±0.82 (s.e.) in the parotid and 10.7 ±3.1 (s.e.) in the submandibular glands. Corresponding values for G/P 99m TcO 4 ‐were 2.70 ±0.34 in the parotid and 5.3 ± 1.2 in the submandibular glands. Values obtained at parotidectomy 1 h after intravenous administration of a mixture containing 125 I ‐ and 99m TcO 4 ‐ to 6 patients were 4.13 ± 0.85 for G/P 125 I‐ and 2.50 ± 0.62 for G/P 99m TcO 4 ‐. G/P 131 I‐ (or G/P 125 I‐) and G/P 99m TeO 4 ‐, derived by both methods, were significantly correlated in parotid and submandibular glands. There was a significant correlation between G/P 131 I‐/G/P 99m TcO 4 ‐ in the parotid glands and G/P 131 I‐/G/P 99m TcO 4 ‐ in the submandibular glands. ‐It is concluded that 1. salivary gland values of 131 I ‐ and 99m TcO 4 , ‐ as measured by scintiscanning are very close to values obtained by direct counting of excised human salivary gland tissue and 2. that the secretion processes in both glands are physiologically related.