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Positive Correlation of Serum Lecithin: Cholesterol Acyltransferase Activity with Relative Body Weight
Author(s) -
Akanuma Y.,
Kuzuya T.,
Hayashi M.,
Ide T.,
Kuzuya N.
Publication year - 1973
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1973.tb00341.x
Subject(s) - medicine , endocrinology , cholesterol , triglyceride , lecithin , basal (medicine) , lecithin—cholesterol acyltransferase , sterol o acyltransferase , obesity , chemistry , serum cholesterol , diabetes mellitus , biology , lipoprotein , biochemistry
. The activity of serum lecithin:cholesterol acyltransferase (LCAT) was measured in 33 subjects who had no apparent diseases except obesity in some cases. Their liver function tests were all within normal limits. The correlations of serum LCAT activity with sex, age, glucose tolerance, relative body weight, basal immunoreactive insulin, and fasting serum cholesterol and triglyceride were studied. – The results indicate that an increase in serum LCAT activity is significantly correlated with increases in relative body weight, serum total cholesterol, serum unesterified cholesterol, serum basal immunoreactive insulin, and serum triglyceride. – At present the physiological significance of serum cholesterol es‐terification is not fully established. However, the present findings suggest an increased turnover of serum esterified cholesterol in obese subjects.